Recent publications
SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase
February 28, 2022
Higgins CB, Mayer AL, Zhang Y, Franczyk M, Ballentine S, Yoshino J, DeBosch BJ. SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase. Nat Commun. 2022 Feb 28;13(1):1074. doi: 10.1038/s41467-022-28717-7. PMID: 35228549; PMCID: PMC8885655.
Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
January 18, 2022
Zhang Y, Higgins CB, Van Tine BA, Bomalaski JS, DeBosch BJ. Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism. Cell Rep Med. 2022 Jan 18;3(1):100498. doi: 10.1016/j.xcrm.2021.100498. PMID: 35106510; PMCID: PMC8784773.
Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response
November 17, 2021
Jeong SJ, Stitham J, Evans TD, Zhang X, Rodriguez-Velez A, Yeh YS, Tao J, Takabatake K, Epelman S, Lodhi IJ, Schilling JD, DeBosch BJ, Diwan A, Razani B. Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response. Autophagy. 2021 Nov;17(11):3740-3752. doi: 10.1080/15548627.2021.1896906. Epub 2021 Mar 11. PMID: 33706671; PMCID: PMC8632292.
A clinical model to predict fibrosis on liver biopsy in paediatric subjects with nonalcoholic fatty liver disease
October 11, 2021
Kulkarni S, Naz N, Gu H, Stoll JM, Thompson MD, DeBosch BJ. A clinical model to predict fibrosis on liver biopsy in paediatric subjects with nonalcoholic fatty liver disease. Clin Obes. 2021 Oct;11(5):e12472. doi: 10.1111/cob.12472. Epub 2021 Jun 9. PMID: 34106515; PMCID: PMC8928096.
Maternal Fructose Diet-Induced Developmental Programming
September 20, 2021
Thompson MD, DeBosch BJ. Maternal Fructose Diet-Induced Developmental Programming. Nutrients. 2021 Sep 20;13(9):3278. doi: 10.3390/nu13093278. PMID: 34579155; PMCID: PMC8467222.